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Preclinical studies have shown it may protect the gastric mucosa from damage caused by NSAIDs, alcohol, and other mucosal irritants
In addition to antagonizing the effect of -MSH at the MC3R and MC4R, AgRP suppresses the basal activity of the MC4R, thus defining AgRP as an inverse agonist
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This occurs because oxidative stressors and toxic substances constantly affect the liver
O (outcome): Studies that included the 5-year OS rate, 5-year EFS rate, or LR rate with or without the following clinicopathologic were included: gender, age, tumor size, depth, location, tumor grade, NF1, surgical margin, chemotherapy, and radiotherapy
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