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The clinical data consistently shows that patients who combine GLP-1 therapy with structured dietary modifications and regular physical activity achieve significantly better outcomes than those relying on medication alone

Gen Comp Endocrinol 252:150161 Shimizu M, Kishimoto K, Yamaguchi T, Nakano Y, Hara A, Dickhoff WW (2011a) Circulating salmon 28- and 22-kDa insulin-like growth factor binding proteins (IGFBPs) are co-orthologs of IGFBP-1

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This changed with recent legislation and the announcement of the BALANCE (Better Approaches to Lifestyle and Nutrition for Comprehensive health) Model in December 2025, which creates a Medicare GLP-1 payment demonstration scheduled to begin in July 2026