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Hyperglycemia induces metabolic and cellular stress that drives VEGF signaling, mitochondrial superoxide production, and induces persistent epigenetic changes, thereby priming inflammatory signaling in glia and endothelial cells ( In human retinal endothelial cells, high glucose is associated with lipidomic shifts consistent with increased PUFA oxidation that promote NADPH oxidase activation and tight-junction disruption

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Foods rich in antioxidants include: Berries: blueberries, strawberries, raspberries, and blackberries Dark chocolate Nuts: pecans, walnuts, pistachios Beans: kidney beans, black beans, pinto beans Vegetables: spinach, kale, broccoli, Brussels sprouts, artichoke Green tea Spices: cilantro, cinnamon, turmeric, cloves Tomatoes Red wine Avoid factors that deplete glutathione Avoid factors that deplete glutathione levels, including these: 3,4 A diet high in processed foods Alcohol Chronic diseases such as diabetes, heart disease, and cancer Excessive or prolonged physical activity Exposure to heavy metals Exposure to pollution, radiation, and environmental toxins Infections Poor nutrition Sleep deprivation Smoking Oral glutathione may not be an effective way to supplement glutathione, as digestive enzymes may break it down

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