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[] The development of multi-target agents such as tirzepatide (GLP-1/glucose-dependent insulinotropic polypeptide [GIP] agonist) has pushed efficacy boundaries further, demonstrating up to 25% weight reduction

Not all patients will qualify for treatment

Without a companion program, its possible to end up with sarcopenic obesity and a higher body fat composition than before starting the meds up to 40% of weight loss can be muscle

It helps maintain mitochondrial membrane potential and prevent the release of pro-apoptotic factors from mitochondria, thereby preserving cell viability (Pang, 2015)

Enzymatic antioxidant defense cannot rely solely on SOD, because that would result in markedly increased tissue damage due to high accumulated levels of intracellular H 2 O 2 , the substrate for production of OH via the Fenton reaction