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126 The upregulation of IDH1 may represent a common metabolic adaptation for diminishing oxidative stress and supporting macromolecular synthesis, consequently promoting tumor growth and therapy resistance

Cabaletta Bio Founded: 2017 Technology / disease area: Autologous CD19 CAR T in autoimmune diseases Lead candidate: rese-cel (formerly CABA-201) Philadelphia-based biotech company Cabaletta Bio is developing autologous CD19-directed CAR T therapies for autoimmune diseases, using an immune reset framing that borrows from oncology CAR T but targets chronic B-cell-driven pathology rather than malignant B cells

Both studies (Study 1 and 2) consisted of a 26-week Main Phase and a 26-week Extension Phase

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Some patients reach their target weight and choose to stay on semaglutide long-term as a maintenance medication, while others discontinue after significant loss and transition to behavioral strategies