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Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day
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Clinically, elevated levels of endogenous GLP-1 have been observed in patients with sepsis (6.35-fold increase), end-stage renal disease (4.46-fold), and burns (2.96-fold), indicating a common physiological response to critical illness (Lebherz et al., 2017)
We were particularly concerned about this limitation, as PCSK1 is lowly expressed in adult cells (16)
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