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Figure 1

Gclm KO mice also exhibit constitutive activation of liver AMP-activated protein kinase (AMPK) pathway and nuclear factor-erythroid 2related factor 2 target genes, and show enhanced ethanol clearance, altered hepatic lipid profiles in favor of increased levels of polyunsaturated fatty acids and concordant changes in expression of genes associated with lipogenesis and fatty acid oxidation

Pyroglutamate may be a promising therapeutic candidate for cognitive dysfunction in schizophrenia and other conditions with glutathione disturbances

MIC stands for Methionine, Inositol, and Choline, which work alongside B12 to support fat metabolism

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