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Despite the accumulation of R5P, knockdown of TKT suppresses tumor growth and sensitizes cancer cells to chemotherapy (75)

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implication in humans is still under investigation, so some GLP1 drugs carry warnings (especially for those with a medullary thyroid carcinoma history)

Some patients have a threshold effect: tolerable constipation at 1.0 mg, sudden severe constipation at 1.7 mg, no further worsening at 2.4 mg

Some individuals pursuing skin health benefits begin noticing subtle improvements in skin brightness or texture, though results vary considerably