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Ultra-low calorie intake: Eating fewer than 1,000 calories daily, which is easy to do accidentally when appetite is dramatically suppressed, triggers metabolic adaptation that actually slows weight loss over time
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GLP-1 agonists reduce hepatic steatosis primarily through weight loss, improved insulin sensitivity, and decreased hepatic glucose production and lipogenesis
GIP activation enhances insulin sensitivity and appears to reduce the GI side effects commonly associated with pure GLP-1 agonists
