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Several questions remain unsolved, including the connection between melanocyte depletion and stem cell exhaustion, the underlying degenerative mechanisms and the biological mediators of cell death

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Individuals with a history of any digestive, cardiovascular, or metabolic diseases which would interfere with glutathione absorption or metabolism, knowingly pregnant and nursing females, and individuals taking daily oral prescription medication were excluded from the study to minimize confounding factors which could influence glutathione levels

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The biologics often act at a higher level of the cascade ( e.g