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Cleavage of this signal peptide is crucial for GLP-1R expression on the cell surface
But the side effects will be overwhelming
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Evidence from metabolic organs suggests a potential biphasic behavior, early contact enrichment and heightened flux followed by late-stage decoupling (Theurey and Rieusset, 2017), raising the possibility that GLP-1R agonists may exert qualitatively different effects depending on whether the limiting factor is excessive Ca 2+ transfer versus structural collapse of tethering and scaffolding networks
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