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Abbreviations: AUC: area under the curve

Theyre not recommended if you have: Gastroparesis or severe GI conditions A personal or family history of medullary thyroid carcinoma or MEN2 genetic syndrome A history of pancreatitis Pregnancy or are breastfeeding Diabetic retinopathy (risk of worsening with rapid glucose drops) Always share your full health history with your providertransparency is critical for safe recommendations

Researchers believe GIP co-activation may have a protective effect on the GI tract, explaining why dual and triple agonists are often better tolerated than single-agonist Semaglutide (which has 44% nausea rates)

Patients with uncontrolled high blood pressure should not use PT-141 until blood pressure is managed

Scirica BM, Bhatt DL, Braunwald E, Steg PG, Davidson J, Hirshberg B, Ohman P, Frederich R, Wiviott SD, Hoffman EB, Cavender MA, Udell JA, Desai NR, Mosenzon O, McGuire DK, Ray KK, Leiter LA, Raz I, Committee S-TS, and Investigators