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GLP-1 receptor activation slows gastric emptying, which can lead to constipation in certain individuals
Two molecules that have been recently involved in oxidative damage and inflammatory response are Nitric oxide (NO) and Carbon monoxide (CO)
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Further studies in pigs revealed that a high degree of NH2-terminal degradation of GLP-1 occured in the hepatic portal system (34), concomitant with the evidence that DPP-4 is found in high concentrations in hepatocytes and endothelial cells (35, 36)
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