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Upon ligand binding, these stimuli initiate the assembly of a key multi-protein signaling complex composed of receptor-interacting protein kinase 3 (RIPK3) and receptor-interacting protein kinase 1 (RIPK1), called necrosome
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A direct link between NOX activity and inflammation is apparent, as NOX2 mediated production of O 2 and resulting increased steady-state H 2 O 2 levels is necessary for NF-KB activation in macrophages (Li et al., 2018) and for microglia proliferation (Mander et al., 2006)
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