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Lastly, while APOE effects dominated brain profiles, sex effects were more prominent in the periphery, which was also in accordance with a previous study in older (16 months old) APOE-TR mice (Shang et al., 2020), suggesting that regardless of age APOE has a major effect on brain bioenergetics

Inhibition of system Xc- expression leads to decreased GSH production, thus affecting GPX4 activity and inducing ferroptosis [40, 41]

L-carnitine is also an antioxidant for the maintenance of good health