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This conversion creates a recycling pathway known as the citrulline-NO cycle, where NOS (nitric oxide synthase) enzymes transform L-arginine into NO and L-citrulline
It's mechanistic
GR is riboflavin (vitamin B2) dependent and GP is selenium dependent
The authors hypothesised that xCT inhibition might be further potentiated by limiting glutamate or glutamine availability, and show that xCT is a compelling therapeutic target for triple-negative tumours
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