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Theoretically, nanoparticles (NPs) encapsulating GLP-1RAs can significantly extend the drugs half-life and promote accumulation of the drug in the joint cartilage, thereby maintaining a high therapeutic concentration for an extended period and improving treatment efficacy

Understandably, this reinforces the importance of continued medication to ensure lasting results something that mustnt be overlooked if youre seeking optimal improvements in your health

Primary Handling editor: Michael Basson, in collaboration with the Nature Medicine team

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If MASLD/NASH is a primary health concern alongside obesity, retatrutide could offer dual benefits that no current medication can match