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10.1007/s00125-007-0633-0 59 Food and Drug Administration (2009)

This randomized, double-blind, placebo-controlled trial in 58 older adults identified as "pre-frail" found an decrease in a Frailty Index score and an improvement in the hand grip test in individuals supplemented with L-carnitine (1.5 g/day) over 10 weeks but not in those given a placebo (118)

In conclusion, our study on zebrafish models revealed that LMNA mutations cause abnormal phenotypes, premature death, decreased fiber size, and muscle dysfunction, reflecting the clinical manifestations of muscular laminopathy

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