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For efficacy outcomes, in case trials reported results for different estimand analyses, we preferably extracted data for the efficacy estimand, which represents on-treatment efficacy without the influence of rescue therapy [14]

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Most probably, the observation period of six months was too short to sensitively detect worsening in visual outcomes, including GCL volume loss, also proven by a recent study in which a delayed decline in visual field and GCL volume after 12 months was seen [39]

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