Fortunately, you cannot overdose on vitamin B12, as it is water-soluble, so adding more is not harmful
Avoid pressing hard enough to hurt
It is available from compounding pharmacies under the authority granted by Section 503A of the Federal Food, Drug, and Cosmetic Act
Furthermore, the KDIGO 2024 guidelines cover combination therapy from the perspective of SGLT2is being first-line therapy, and long-acting GLP-1 RAs being an add-on in adults with CKD and T2D who have not achieved individualised glycaemic targets despite use of metformin and SGLT2is, or who are unable to use those medications [2]
Sometimes, the most significant breakthroughs come from refining what we already have, making established molecules more robust, more reliable, and more effective for study