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doi:10.1016/j.expneurol.2016.01.007 16

Standards: NGSS HS-LS1-3: Explain how feedback mechanisms maintain homeostasis

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Consistent with the incretin-mediated delivery of the PPAR// agonist, the metabolic effects of GLP-1GIPLani were blunted in DIO mice with pharmacological or genetic inhibition of GLP-1R, GIPR or PPAR, and vanished in double-incretin receptor knockout (DIR-KO) mice

The EHR cohort was younger and had a larger proportion of men than the survey cohort (median age 44 years versus 52 years, and 37% male versus 18%), and both of these factors may contribute to some of the apparent difference in weight loss efficacy between self-report and EHR data