It also implies that any beneficial effects on vascular or RPE pathology may be mediated indirectly, either through neuronal signaling pathways within the retina or via systemic anti-inflammatory and metabolic improvements
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Greenwood-Van Meerveld B, Tyler K, Mohammadi E, Pietra C
It modulates the ratio of acetyl-CoA to CoA in the mitochondria, which affects pyruvate dehydrogenase activity and glucose oxidation