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To understand the underlying mechanisms, inhibitors targeting the Notch pathway (DAPT) and NF-B pathway (BMS) were also applied to HUVEC and murine CLI models

Once mixed, keep the vial refrigerated between 36 and 46 degrees Fahrenheit (2 to 8 degrees Celsius)

The material below is summarised strictly for research-use-only (RUO) context and is not medical advice, nor a dosing guide, nor a suggestion that either compound is safe or effective in people

TB-500 may therefore be hypothesized to encourage angiogenesis by pairing a cytoskeleton-linked rise in endothelial motility with signaling shifts that elevate pro-angiogenic programs such as VEGF-A and Ang2/Tie2 through Notch/NF-B coupling in damaged cellular structures

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