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In experimental models of Wilson disease, copper accumulates in the nuclear region of hepatocytes, where these metabolic nuclear receptors are primarily located [130]
Intestinal absorption occurs predominantly in the small bowel through active transport systems, specifically mediated by organic cation transporters (OCTN family)
Adults over the age of 60 are at the highest risk because our ability to absorb B12 from food naturally declines as we age
TB-500 Overview: National Center for Biotechnology Information (2026)
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