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Semaglutide and topiramate are two medications often used to help with weight loss
Foundational work from the de Keizer laboratory (Baar et al., Cell, 2017) reported that the peptide perturbs the FOXO4-p53 association, leading to p53 nuclear exclusion and apoptosis that appeared preferential to senescent cells in cultured cells and aged mouse models
Its important to understand how they work and where they come from
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