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For the purpose of this study, we classified sporadic malignant peripheral nerve sheath tumor cases as 'certain' when the diagnosis of malignant peripheral nerve sheath tumor was certain (tumor originating in a peripheral nerve or in a pre-existing nerve sheath tumor, usually a neurofibroma) or focal S100 protein/SOX10 positivity in the absence of other markers and absence of specific simple genomic alteration), or as 'probable' when histologic features was typical but supportive immunohistochemical and clinical data were lacking (not originating from a nerve or benign nerve sheath tumor, absence of S100 protein/SOX10 expression, absence of other immunohistochemical markers, and absence of specific simple genomic alteration)

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