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As IKK- is the direct upstream kinase that phosphorylates IB-, leading to its degradation, we next examined whether decreased TNF-induced IB- phosphorylation by H 2 O 2 treatment was due to its effects on IKK- activity
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In addition to gastrointestinal side effects, participants also reported mild-to-moderate neuropsychiatric issues, primarily anxiety, irritability and sleep disturbances
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These mice received an intraperitoneal injection of isotonic saline
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