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Diabetes 51 , S434442 (2002)
Key Points Semaglutide causes diarrhea through multiple mechanisms slowing stomach emptying while speeding up colon activity and affecting nutrient absorption Higher semaglutide doses used for weight loss (Wegovy) cause more GI issues than diabetes doses (Ozempic) Most people see improvement over time as their body adapts to the medication The diarrhea doesn't mean the drug is "working better" Starting semaglutide (Ozempic or Wegovy) can be an exciting development in your diabetes or weight loss journey
Hunt B, Malkin SJP, Moes RGJ, Huisman EL, Vandebrouck T, Wolffenbuttel BHR
Oral semaglutide has an advantage over oral insulin in that a fixed dosage can be safely administered with minimal hypoglycemic risk
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