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2.5.15 Anti-CD3/CD3R 2.5.15.1 Muronomab-CD3 CD3 is a core component of the T cell receptor complex, and oral anti-CD3 antibodies induce tolerogenic effects through T cell anergy, regulatory T cell induction, and anti-inflammatory cytokine production in gut-associated lymphoid tissue, though clinical development was limited by manufacturing discontinuation

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In addition, GLP-1/glucagon and GLP-1/GIP dual receptor agonists and GLP-1/GIP/glucagon triple receptor agonists have shown the potential to reduce blood glucose levels and body weight through their effects on islets and peripheral tissues, improving beta cell function and stimulating energy expenditure

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