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Evidence has indicated that regulating the gene expression of TRP-1 and TRP-2 by cAMP is directly associated with MITF, which binds to the M-box sequence (AGTCATGTGCT) located in the tyrosinase distal elements (TDEs) after its activation (22)

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Therefore, apoptosis is frequently associated with the mechanisms that cause sepsis-induced cardiac depression [70,71,72]

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