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For example, Medicare Part D plans still require beneficiaries to pay premiums and cost-sharing, and those without supplemental coverage or who do not qualify for the Low-Income Subsidy face higher financial barriers
To demonstrate the advantages of bivalent target binding through the full IgG format for enhancing avidity and selectivity, compared to most clinically approved bispecific T cell engagers that rely on monovalent binding, we introduced mutations (H91A and Y92A) in the complementarity-determining regions of Her2 to generate Her2 variants with reduced target binding affinity
