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In CRISPR-engineered iPSC-derived microglia and neurons, plus primary autopsy microglia and brain tissue, SORL1 deletion triggered endoplasmic reticulum stress, interferon signaling, lipid-droplet accumulation, and impaired phagocytosis

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To block nonspecific immunoreactivity, sections were treated with the blocking solutions (0.2% Casein in PBS for the fluorescent secondary antibody method, TSA Biotin System kit for the TSA method)

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