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For the pathways using precursors that require a phosphoribosyl moiety, such as NAM and nicotinic acid (NA), PRPP is required 22

In species where aromatic hydroxylation of amphetamine is the major metabolic pathway, p -hydroxyamphetamine (POH) and p -hydroxynorephedrine (PHN) may contribute to the pharmacological profile of the parent drug

1d was driven by bioisosteric replacement of the fragments bound to subpockets A-C, scaffold-hopping, de novo design, and medicinal chemistry and was facilitated by SZMAP/GamePlan 37 , vBrood 38 , and MOE software 39