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Lifestyle changes could absolutely control the weight except very few people can maintain them without GLP-1 support and those that can, didnt become overweight in the first place

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Consequently, the skin remains loose and saggy, particularly in areas with significant fat deposits, such as the upper arms

SURMOUNT-2 in adults with obesity and type 2 diabetes showed mean weight reductions of 12.8% at 10 mg and 14.7% at 15 mg over 72 weeks (Garvey et al., 2023)

Endocrine (Thyroid & Diabetes): Levothyroxine (Synthroid) is one of the single most-prescribed drugs, used to replace thyroid hormone in hypothyroidism