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Its the hallmark of professional, high-impact research
Larrea tridentata (creosote bush), an abundant plant of Mexican and US-American deserts and its metabolite nordihydroguaiaretic acid
(2011) used the histone deacetylase inhibitor depispeptide to reverse DNA hypermethylation and alter the histone modification pattern at GSTP1 promoter, including a reduction of H3K9me2/3 and H3K27me2/3 and an increase of H3K18Ac, thereby inducing GSTP1 mRNA re-expression
Both methods have their strengths
[PMID: 2742854] PubMed record related to this compound for laboratory literature review
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