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471 To enhance the delivery of neutrally charged oligonucleotides, Gait and Wood 472 developed a series of arginine-rich CPPs named [PNA/PMO]-internalized peptides (Pip), including Pip2a, Pip2b, Pip5e, and Pip6a

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Nanoparticles (NP) offer a potential alternative approach because they can be engineered for targeted delivery, controlled release, and tissue-specific accumulation