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The trade-off is clear: you sacrifice the speed and magnitude of weight loss seen in clinical trials at higher doses in exchange for a more tolerable experience and a protocol that is easier to sustain over time
doi: 10.3389/fendo.2021.735824 15 ChoiHJParkCLeeYKHaYCJangSShinCS
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No evidence for a major influence of metabolic genotype at CYP2D6
31,35-37 Prospective trials are needed to further explore this potential adverse event and worsened DR, which is the central premise of the ophthalmic FOCUS trial that is expected to release results in 2026
