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5-Amino-1MQ is used by researchers as a tool to study NNMT inhibition and downstream cellular pathways in controlled laboratory models
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Observational studies A large number of cross-sectional and prospective cohort studies have associated elevated blood homocysteine concentrations with measures of poor cognitive scores and increased risk of dementia, including Alzheimer's disease (reviewed in 67, 69)
Small molecule inhibitors of nicotinamide N-methyltransferase (NNMT). Journal of Medicinal Chemistry, 59(19), 90399056
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