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Providers often recommend backup contraception (such as condoms) during the first weeks of GLP-1 therapy initiation, when dosing adjustments are most frequent and gastric changes are most pronounced
To generate pLJM1-EGFP transfer plasmids, four copies of inhibitory peptide or control peptide with mutated binding motif spaced out by a flexible GST linker and fused to C-terminus of EGFP were obtained (GenScript)
[1] The structured progression was essential for balancing metabolic benefits with patient tolerability
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They may go away after a few weeks as the body gets used to the drug
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