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Several real-world studies based on administrative data and pharmacy reports have demonstrated that reduced adherence to antidiabetic therapy is associated not only with poorer glycemic control but also with a significant increase in overall mortality and hospitalizations for all causes [70, 71]
Tachyphylaxis is why most people eventually have less side effects with GLP-1 drugs
Risk factors include vegetarian or vegan diets, age over 50 (reduced gastric acid impairs absorption), proton pump inhibitor use, prior gastric surgery, and Type 1 diabetes
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