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NAC may help by supporting antioxidant defenses and reducing oxidative stress, though its effects vary depending on the population and fertility issue being studied.32 In men, one randomized trial found that 600mg of NAC, selenium, or the combination improved semen parameters, with the combination producing stronger effects than either ingredient alone.23 In women undergoing assisted reproduction, NAC has also been studied for oocyte and embryo quality, though this research is still relatively early and not definitive.24 PCOS NAC has attracted particular interest in PCOS, where insulin resistance, inflammation, and oxidative stress often overlap.17 Researchers think NAC may help by improving insulin sensitivity and reducing oxidative stress, which may, in turn, support ovulation and reproductive function

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Elucidation of the molecular mechanisms underlying sorafenib-induced hepatotoxicity

While NAC is generally considered safe and well-tolerated, some individuals should avoid it, including: People with asthma (NAC may trigger bronchospasm)

Hemin-induced platelet activation and ferroptosis is mediated through ROS-driven proteasomal activity and inflammasome activation: protection by melatonin