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(2025) T2DM: 46.5% discontinued by 1 year 64.1% discontinued by 2 years Without T2DM: 64.8% discontinued by 1 year 84.4% discontinued by 2 years Key Factors Linked to Discontinuation: Higher rates among patients without T2DM Age 65 years More likely to discontinue Higher weight loss during treatment Associated with lower discontinuation rates Moderate to severe GI side effects Higher likelihood of stopping treatment Higher income (T2DM only) Lower discontinuation rates Reinitiation of GLP-1: Source: Rodriguez PJ, Zhang V, Gratzl S, et al
This gives the injection site time to settle and allows the initial side effect window to pass before you add physical stress
If you are comparing where injectable semaglutide fits among other therapies, the Injectable Type 2 Diabetes Medications List gives broader context on injection-based options
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I do not discourage patients from using BPC-157 for its documented properties (gut healing, tissue repair) if they understand the risks
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