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GHK-Cu's mechanisms appear to involve antioxidant protection of neurons from oxidative damage, anti-inflammatory effects reducing microglial activation and neuroinflammation, modulation of gene expression patterns favoring neuroprotection, and potential effects on protein aggregation reducing pathological deposits
Blood pressure changes receive mixed reports
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Long-term metformin use (typically over three years) and higher doses (2g daily) increase the risk of clinically significant B12 deficiency
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