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Melanin deposited in the epidermis undergoes natural turnover as keratinocytes desquamate (shed), and without continued MC1R stimulation, melanocytes revert to baseline synthetic rates

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DOI: 10.1097/PAS.0b013e3182a0a150 46

Beyond allowing patients to significantly reduce their weight, theyve been shown to have a constellation of other health benefits, like lowering the risk of heart disease and staving off diabetic kidney disease, Parkinsons, and Alzheimers

This activation triggers pulsatile GH secretion while maintaining upstream hypothalamic regulation