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Drugs developed based on this hypothesis, however, have not met with much success in recent times
Such substitution could be made separately or in combination with substitution(s) at other sites in the catalytic triad, which includes His 193 and Asp 242
Lillys Mounjaro (tirzepatide), a GIP/GLP-1 dual agonist, demonstrated cardiovascular protection in landmark head-to-head trial, reinforcing its benefit in patients with type 2 diabetes and heart disease
Hum Reprod 31:750762
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