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Originally derived from pineal gland extracts, Epithalon has become a subject of scientific investigation for its possible role in supporting healthy aging

10.1001/jama.296.1.87

Special Precautions Administration of high doses of the oral formulations of levocarnitine for long periods of time is not recommended in patients with severely compromised renal function or in ESRD patients on dialysis due to the fact that major metabolites formed following oral administration trimethylamine (TMA) and trimethylamine-N-oxide (TMAO) will accumulate since they can not be efficiently removed by the kidneys

In each of the three cases, the mean steady-state plasma concentration is 10 mg/L

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