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However, GIP biology is multimodal, and both GIPR agonism and antagonism provoke weight loss when administered together with GLP-1R agonists 3
This can involve the release of NO on its own (Turkovic et al., 2004), as well as maintained NO system function against NOS blockade (L-NAME) or overfunction (L-arginine) (for review, see Stupnisek et al., 2015
2006 Dec;291(6):E1290-4
Some patients follow an initial loading phase over several weeks, then transition to a maintenance schedule if ongoing support is needed
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