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C., & Stefanski, A., for the SURMOUNT-1 Investigators

Our study is subject to several limitations

IGF-1 LR3 is a modified analog of human Insulin-Like Growth Factor-1, engineered with two structural changes an arginine substitution and a 13-amino acid N-terminal extension that reduce its binding to IGF-1 binding proteins

Furthermore, the quality of evidence across studies varied, with some trials having a high risk of bias due to issues such as inadequate blinding, incomplete outcome data, and selective reporting

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