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Graphical abstract Access this article Similar content being viewed by others Data availability Data from the pharmacokinetic model and the molecular dynamics simulations are available at References Aroda VR, Blonde L, Pratley RE (2022) A new era for oral peptides: SNAC and the development of oral semaglutide for the treatment of type 2 diabetes

Tirzepatide is a single-molecule dual receptor agonist studied for its combined activity at the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors

The originators expectation should be that a successful reformulation will face Paragraph IV challenges to its formulation patents, not just the original compound patents