The results demonstrated that resveratrol administration decreased plasma levels of thyroid-stimulating hormone (TSH) as well as hypothalamic mRNA levels of thyrotropin-releasing hormone (TRH)
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ROS Scavenging and Gene Regulation: Oxidative stress upregulates the Microphthalmia-associated Transcription Factor (MITF), which acts as the primary on-switch for melanin production [5]
Huang K, ONeill KL, Li J et al (2019) BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis
Within this mechanistic framework, natural compounds with antioxidant and anti-inflammatory properties, including vitamins C and E, glutathione precursors, CoQ10, L-carnosine, polyphenols including quercetin, resveratrol, and curcumin, and saffron metabolites like crocin and safranal show biological plausibility and preliminary efficacy on biochemical and behavioral endpoints